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Index > Protein center > TNFSF10(Gene name) > Human
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  • TNFSF10 (Gene name),
  • Tumor necrosis factor ligand superfamily member 10 (Protein name ),  TNF10_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TNFSF10(APO2L;TRAIL);
    Protein name:
    Tumor necrosis factor ligand superfamily member 10;
    Alternative:
    TNF-related apoptosis-inducing ligand(Protein TRAIL);Apo-2 ligand(Apo-2L);
    CD:
    CD253;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer.
    Function:
    Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
    Subcellular Location:
    Membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    281
    Sequence:
    50:
    MAMMEVQGGP | SLGQTCVLIV | IFTVLLQSLC | VAVTYVYFTN | ELKQMQDKYS | 
    100:
    KSGIACFLKE | DDSYWDPNDE | ESMNSPCWQV | KWQLRQLVRK | MILRTSEETI | 
    150:
    STVQEKQQNI | SPLVRERGPQ | RVAAHITGTR | GRSNTLSSPN | SKNEKALGRK | 
    200:
    INSWESSRSG | HSFLSNLHLR | NGELVIHEKG | FYYIYSQTYF | RFQEEIKENT | 
    250:
    KNDKQMVQYI | YKYTSYPDPI | LLMKSARNSC | WSKDAEYGLY | SIYQGGIFEL | 
    281:
    KENDRIFVSV | TNEHLIDMDH | EASFFGAFLV | G
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    String:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 10
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    E0139h
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    96T
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    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 10
    Cat.:
    E0139m
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    MSDS:
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    96T
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    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 10
    Cat.:
    U0139m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 10
    Cat.:
    U0139h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 10
    Cat.:
    P0139Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 10
    Cat.:
    P0139Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 10
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 10
    Protein for Human Tumor necrosis factor ligand superfamily member 10
    Protein for Human Tumor necrosis factor ligand superfamily member 10

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    Linearity
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    References
    1. 1.
      "Identification and characterization of a new member of the TNF family that induces apoptosis."
      Wiley S.R. , Schooley K. , Smolak P.J. , Din W.S. , Huang C.-P. , Nicholl J.K. , Sutherland G.R. , Davis-Smith T. , Rauch C. , Smith C.A. , Goodwin R.G.
      Immunity3:673-682(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family."
      Pitti R.M. , Marsters S.A. , Ruppert S. , Donahue C.J. , Moore A. , Ashkenazi A.
      J. Biol. Chem.271:12687-12690(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
    4. 4.
      "Novel TRAIL splice variant TRAIL-delta."
      Woods D.C. , Haugen M.J. , Johnson A.L.
      Submitted (2007-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Thalamus.
    6. 6.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lymph.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    9. 9.
      "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5."
      Hymowitz S.G. , Christinger H.W. , Fuh G. , Ultsch M. , O'Connell M. , Kelley R.F. , Ashkenazi A. , de Vos A.M.
      Mol. Cell4:563-571(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 114-281
    10. 10.
      "Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation."
      Mongkolsapaya J. , Grimes J.M. , Chen N. , Xu X.-N. , Stuart D.I. , Jones E.Y. , Screaton G.R.
      Nat. Struct. Biol.6:1048-1053(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 119-281
    11. 11.
      "2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity."
      Cha S.-S. , Kim M.S. , Choi Y.H. , Sung B.J. , Shin N.K. , Shin H.C. , Sung Y.C. , Oh B.-H.
      Immunity11:253-261(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 114-281
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